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ALKLOZAN-10%; 20%

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1. GENERAL INFORMATION
1.1 Alklozan 10% and Alklozan 20%

1.2 The drug by its appearance is a fine crystalline powder with light gray to brown color.

1.3. Each gram of Alklozan 10% contains 50 mg albendozole and 50 mg closantel as active ingredients. Each gram of Alklozan 20% contains 100 mg albendozole and 100 mg closantel.

1.4 The drug is pre-packed in powder form by 50, 100, 250, 500 or 1,000 g in polymer bags or by 250, 500, 1000, 2000 and 3000 g in polymer vessels.

1.5 The drug should be stored in dry, dark place at the temperature range 0°C to +30°C. Shelf life is 3 years.

2. PHARMACOLOGICAL PROPERTIES
2.1 Mechanism of albendozole action as a part of the drug is disruption of carbohydrate metabolism in helminthes, which leads to its destruction and withdrawal from the animal body. After oral administration albendozole is rapidly absorbed by gastrointestinal tract and penetrated into organs and tissues; it is mainly eliminated from the body with urine and faeces. Due to its egg-killing action it reduces pasture infestation by helminthes.

2.2 Mechanism of the closantel action is inhibition of oxidation phosphorylation in parasites. Specific drug action is stimulation of ATF-enzyme which leads to disruption of phosphorylation process and electron transport, thus changing metabolism energy of parasite and leading to its death.

2.3 Albendozol and closantel included in the drug having synergistic effect, cause death to internal parasites and external parasites of ruminants, including trematodes, nematodes, cestodes and those resistant to benzimidazole, as well as gadfly larvae and sarcoproid mites.

2.4 By toxicity to warm-blooded animal the drug belongs to the Hazard Category 4 - "low risk drugs" (GOST 12.1.007). The drug does not have teratogenic, embryo toxic, mutagenic and allergenic properties in therapeutic dose.

 

3. DRUG USAGE PROCEDURE
3.1 The drug is used for deworming of cattle, sheep and goats in the following diseases: - fascioliasis, dicrocoeliosis, monieziasis, dictyocaulosis, ostertagiosis, haemonchosis, trichostrongylosis, cooperiosis, esophagostomiasis, eodemagenosis; The drug is used for treatment of hypodermosis in cattle and oestrosis and psoroptosis in sheep.

3.2 Drug usage and dosage. The drug is administered parentally either individually or by group mixed with food. The drug is administered one time. During helminthic and gadfly invasions Alklozan 20% shall be administered based on 40 mg / kg of animal weight and Alklozan 10% based on 80 mg / kg of animal weight one time, individually or in group method mixed with food or in aqueous suspension in bottle.

During psoroptosis in sheep the drug is administered twice with 7 days interval and with preventive treatment in farms contaminated with psoroptosis the drug is used once in the following dose: Alklozan 20% - 100 mg / kg body weight, and Alklozan 10% - 200 mg / kg body weight. Deworming of animals should be carried out twice a year: two weeks before withdrawal to pasture and before stabling. Treatment of animals against hypothermosis, eodemagenosis and oestrosis shall be made after end of summer gadfly. Treatment of sheep against psoroptosis shall be carried out in any period of the year upon prescription.

3.3 Prior to mass deworming every batch of the drug shall be pre-tested in a small group of animals (5-10 animals). In absence of complications within 3 days you can start treatment in all livestock.

3.4 Adverse effects. No side effects have been observed by using the drug in recommended doses.

3.5 Contraindications. Do not use in animals with known hypersensitivity to the drug components. Do not use simultaneously with organochlorine and chlororganic antiparasitic drugs. The drug shall not be used in acute fascioliasis, during breeding period, in sick animals with infectious diseases and emaciated animals. It is also restricted to use the drug in sheep, goats and pigs in the first half, and in cows - in the first trimester of pregnancy. Do not use the drug in milking animals producing milk for human consumption.

3.6 Meat of cattle and sheep can be used for food purposes 20 days after the last drug administration. During compulsory slaughter prior specified deadlines, such meat can be used as food for fur-bearing animals and in the production of meat and bone tankage.  

 

4.  INDIVIDUAL PREVENTION MEASURES
4.1 All operations with the drug shall be made in protective clothing (dressing, headwear, rubber goggles). In case of accidental contact of the drug with skin or mucous membranes you must rinse with large amount of water.

4.2 Do not drink, smoke and eat during operations.

4.3 At the end of operations you should wash your hands with warm water and soap; Wash and dry your gloves.

4.4 Do not use containers under the drug for food purposes.  

 

5. CLAIMS PROCEDURE
5.1 In case of inconsistency of the drug with requirements of this Instruction, its use should be discontinued and reported to the Uzbek state scientific and veterinary drugs control laboratory at: 700178, Tashkent, No.1a, A.Yunusov Street. Tel. / Fax: 228-76-14, 229-30 - 47. E-mail: uzgnkl@rambler.ru. Simultaneously unpacked drug package should be sent to the laboratory address with the drug in quantity previously agreed with laboratory including detailed description of the nature of complications.