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IMISAN

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1. GENERAL INFORMATION
1.1. Imisan is a drug as solution for injection used for treatment and prevention of blood protozoan diseases in cattle and ruminants, horses and dogs.

1.2. Imisan as an active substance contains 120 mg imidokarb dipropionate in 1 ml.

1.3. Imisan is a yellow solution for injection.

1.4. Imisan is prepackaged by 10, 20, 50,100 ml in dark glass vials or bottles with suitable capacity, sealed with rubber stoppers and covered by aluminum caps. Imisan should be stored with caution (see list B) in a dry, dark place within the temperature range +2°C to +25° C. 

Shelf life is 2 years from the date of manufacture if stored under specified storage conditions.

 

2. PHARMACOLOGICAL PROPERTIES
2.1 Active ingredient is imidokarb dipropionate active against pathogens of babesiosis, nuttalliosis, anaplasmosis. Mechanism of action is based on inhibition of polyamines metabolism in blood parasites.

2.2 After parenteral administration therapeutic concentration of imidokarb dipropionate in blood shall be achieved in 18-24 hours and retained in blood at the piroplazmastatic level within 4-6 weeks. Imidokarb dipropionate is accumulated mainly in liver and kidneys; it is eliminated primarily with urine unchanged.

2.3 Imisan is a low-hazardous substance according to the impact degree on body (4 Class of hazard according to GOST 12.1.007-76).

 

3. DRUG USAGE PROCEDURE
3.1 Imisan is used for treatment and prevention of blood protozoan diseases (babesiosis, nuttaliosis, anaplasmosis and mixed invasions) in cattle and ruminants, horses and dogs.

3.2 Imisan is administered in animals intramuscularly in the neck area (cattle, horses and sheep) or subcutaneously in the neck area (dogs) with observance of aseptic and antiseptic rules in the following doses:

Species  Imisan dosage 
Babesiosis  Anaplasmosis Mixed invasion 
For treatment purpose 
Cattle  2,0 ml per 100 kg 2,5 ml per 100 kg 2,5 ml per 100 kg
Ruminants  0,2 ml per 10 kg - -
Horses, donkeys, mules 2,0 ml per 100 kg - -
Dogs 0,25-0,5 ml per 10 kg - -
For preventive purpose
Cattle - - 2,5 ml per 100 kg
Horsesdonkeysmules 2,0 ml per 100 kg - -
Dogs 0,5 ml per 10 kg - -

In order to eliminate pathogens and B.caballi in horses, donkeys and mules the treatment is carried out as follows:

Species  Dosage, ml/100 kg of animal weight 
B.caballi B.equi
Horses  By 2 ml twice with 24 hour interval  By 2 ml four times with 72 hour interval
Donkeys and mules  By 2 ml twice with 24 hour interval -

Imisan with medical purpose is used in animals with clinical signs of disease. Sick animals are left in quiet and in addition symptomatic drugs are prescribed depending on physiological conditions.
For prevention purposes the drug is administered upon discover of clinical signs of babesiosis, anaplasmosis and / or mixed infestation in one or two animals from a group or within a week after transfer of animals into disadvantaged according to diseases properties:
- in cattle - 1 time every 6 weeks;
- in horses, donkeys, mules and dogs - 1 time every 4 weeks.

3.3 Specific instructions. During drug administration in sheep and dogs it is required to use syringes with 0.1 ml scale interval. Dogs must be under veterinarian supervision within 15 minutes after injection. It is recommended to use antihistamines simultaneously during this drug administration in dogs.
If calculated volume of this solution exceeds 10 ml, it should be administered in two-three sites of animal to avoid the pain effect.
Treatment of animals by Imisan should be made veterinarian or veterinary assistant.
Before mass treatment each lot of the drug should be tested on a small group of animals (5-10 animals). In the absence of complications within 3 days you can start with treatment of all livestock.

3.4 Contraindications. This drug is not administered subcutaneously or intravenously (except for dogs). Do not use the drug for 4 weeks after vaccination with a live vaccine against babesiosis and anaplasmosis. It is restricted to use simultaneously with organochlorine and organophosphorus compounds and cholinesterase inhibitors as well.

3.5 Side effects. Any side effects and complications shall not be observed in animals if Imisan is administered in accordance with recommended doses according to these instructions. In rare cases, there may be local reaction in the form of hyperemia or painful swelling in the injection site, which disappears after 1-2 days. Repeated administration may be accompanied by decrease in blood pressure, and during drug overdose bradycardia, frequent and irregular breathing, anorexia, tremor may be observed.
When animal has individual hypersensitivity to the drug possible signs of complications (depression, anxiety, excessive salivation, lacrymation, sweating, muscle tremors, frequent urination and defecation) may be observed, in such cases 1% solution of atropine shall be administered subcutaneously.
Intoxication may be developed during mass death of blood parasites and destruction of red blood cells in animals. In such cases intensive care should be conducted including intravenous infusion of electrolytic solutions and symptomatic treatment.

3.6 Slaughter of cattle and sheep for meat shall be allowed not earlier than 45 days after the last Imisan administration; meat of animals during urgent slaughter before expiry of specified period can be used for production of meat and bone tankage. Milk of dairy cows may be used for food no earlier than 7 days after the last drug administration. Before expiry of this term the milk after boiling shall be used for animal feed. Milk of dairy sheep treated by Imisan shall not be used for food purposes during entire period of lactation.  

 

4. INDIVIDUAL PREVENTION MEASURES
4.1 A person working with this drug shall follow general personal hygiene regulations and safety precautions. In case of accidental contact of drug with skin or mucous membranes it should be immediately rinsed with plenty of water.

4.2 Do not drink, smoke or eat during handling the drug.

4.3 After finishing work wash your hands with warm water and soap; Wash and dry your gloves.

4.4 It is restricted to use containers under drug for food purposes.

 

5. CLAIMS PROCEDURE
5.1. In case of complications after drug administration its use should be discontinued and reported to the Uzbek State Scientific and Veterinary Drugs Control Laboratory at: (700178, Tashkent, Karakamysh 2/4, No.1a Yunusov str.), and to the drug manufacturer. Simultaneously samples of drug’s lot should be sent to the Uzbek State Scientific and Veterinary Drugs Control Laboratory samples expelled Series drug that caused complications in animals, with detailed description of complications.