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KALSIY XLORID-10%

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1GENERAL INFORMATION
1.1 Calcium chloride 10% solution for injection.

1.2 The drug is a sterile clear, colorless solution without mechanical impurities.

1.3 The drug is available in glass vials by 50, 100, 200, 250 and 450 ml.

1.4 This drug should be stored in dark place, protected from direct sunlight within the temperature range +5°C to +25°C. Shelf life 3 years from date of manufacture if stored under specified storage conditions.

2. PHARMACOLOGICAL PROPERTIES
2.1 Calcium chloride plays an important role in the life of organism. It activates reticulo-endothelial system and phagocytic function of leukocytes, improves the tone of sympathetic nervous system, increases release of adrenaline and accelerates production of many enzymes.

2.2 Calcium ions are necessary to reduce skeletal and heart muscles, generation of bone tissue and blood clotting. Calcium ions shall compact walls of blood vessels, thereby exhibiting anti-inflammatory effect and prevent development of edema. Calcium is engaged in blood clotting and promotes prothrombin conversion into thrombin.

 

3. DRUG USAGE PROCEDURE
3.1 Calcium chloride 10% solution for injection is used as:

- inflammatory drug against pneumonia, pleurisy, peritonitis, toxic liver damage, parenchymatous hepatitis, nephritis, during radiation sickness, toxic pulmonary edema, hyperemia and edema of lungs, laryngeal edema, edema disease in pigs;
- hemostatic drug against nose, lung, uterine bleeding and post-operative bleeding;
- desensitizing agent against allergic diseases (asthma, serum sickness, itchy skin, scarlatina in horse, chronic urticaria fever in horses and cattle) and allergic complications after use of medicines;
- soothing and normalizing agent for nervous system against vegetative neurosis, eclampsia in dogs, acetonemia in cows, paralytic myoglobinuria in horses.
The drug is used in obstetric practice against endometritis, metritis, for stimulation of maternity activity, acceleration of delayed placenta separation in animals, prevention of abortion, against milk fever, postnatal hematuria in cows.
The drug is used during hypotension and atony of proventriculus, hemorrhagic gastroenteritis as well as against tetany in young animals, to increase the level of calcium in blood and relieving convulsion.
The drug is also prescribed as antidote against poisoning by magnesium salts, oxalic acid, soluble salts of fluorine and oxalic acid, sodium salt.

3.2 Calcium chloride 10% solution for injection should be administered slowly intravenously. Maximum single dose (in ml per animal):
- Horses                             100-300 ml
- Cattle                              150-400 ml
- Ruminants                       10-30 ml
- Pigs                                10-30 ml
- Dogs                               5-15 ml

3.3 During chronic diseases Calcium Chloride 10% solution for injection is recommended in combination with antihistamine drugs.

3.4 Adverse effects. The drug does not cause any side effects in animals and complications if administered in recommended doses and correct method of administration. Ventricular fibrillation of heart may occur during rapid injection.

3.5 Contraindications. The drug should not be administered subcutaneously or intramuscularly, as it causes severe irritation and tissue necrosis.
If during improper injection a part of the drug runs subcutaneously or intramuscular it is necessary to prevent tissue necrosis around the injection site to inject a large amount of isotonic sodium chloride 0.9% solution.
Injection of calcium chloride 10% solution is restricted during liability to thrombosis and increased level of calcium in blood.

3.6 There are no restrictions for slaughter of animals and use of animal products for food purposes.

 

4. CLAIMS PROCEDURE
4.1 In case of complications after drug administration its use should be discontinued and reported to the Uzbek State Scientific and Veterinary Drugs Control Laboratory at: 700178, Tashkent, No.1a, A.Yunusov str.,Tel/Fax: 228-76-14, 229-30-47. E-mal: uzgnkl@rambler.ru. Simultaneously unpacked drug package should be sent to the laboratory address with the drug in quantity previously agreed with laboratory including detailed description of the nature of complaints regarding its inconsistency with these Instructions.