1.1 Kloprostin

1.2 Cloprostenol is an active ingredient of the drug, which is a synthetic analogue of prostaglandin F2α. The drug by its appearance is a clear, colorless solution.

1.3 The drug is available in vials by 10, 20 and 50 ml in the form of clear, colorless solution for injection containing 0.25 mg cloprostenol in 1 ml of the drug.

1.4 The drug should be stored with caution (see list B) in dry, dark place within the temperature range + 4°C to +25°C. Shelf life is 18 months from date of manufacture under specified storage conditions.

2.1 Cloprostenol has luteolytic (resorbable) action on the ovary yellow body, and relieves inhibitory effect of progesterone on hypothalamic-pituitary complex, which promotes growth of follicles in ovaries and increase the level of estrogen in blood, estrum manifestation, oestrus and subsequent ovulation of mature follicles. Interval between drug administration and the first signs of estrus is 48-72 hours.

2.2 The drug increases contractile function of uterus and exhibits biological effect only if yellow bodies are actively functioning in ovaries.


3.1 Kloprostin is administered intramuscularly for estrus synchronization in cows and heifers; for treatment of cows with lutein and follicular cysts, corpus lutem persistens, uterus subinvolution and endometritis; for treatment and prevention of functional disorders of the pigs ovaries, inducing and synchronizing farrowing; non-disclosure of uterine cervix in sheep; abortion in animals (by prescription).

3.2 Dosage and Administration.
Estrus synchronization in cows and heifers: 2 ml of the drug is administered twice with 10 days interval. The first dose of the drug is administered in any phase of sexual cycle (in cows 40 to 60 days after delivery). In absence of excitation stage on the 11th day after first administration the second dose should be injected, and on the 14th day (after 72-76 hours after second injection) frontal artificial insemination shall be performed (regardless of external signs of estrus) with repeated insemination on the 15th day.
Treatment of cows with lutein cysts in the ovary: Kloprostin is administered by single dose 4 ml. In order to increase therapeutic efficiency the drug is administered in the same dose simultaneously with subcutaneous injection of gonadotropin PMS (pregnant mare serum) 2.5-3.0 thousand mouse units (MU).
For treatment of follicular ovarian cysts in cows chorionic gonadotropin shall be injected subcutaneously once by 4-5 thousand units or intramuscularly Surfagon drug by 5 ml within three days. After 10-12 days animals that did not display estrus, shall have Kloprostin injected by 2 ml.
In cows with corpus lutem persistens Kloprostin shall be administered with a dose 2 ml and artificial insemination shall be carried out with a first sign of estrus. If it does not occur, it is necessary repeatedly inject 2 ml of the drug on the 11th day after first injection, followed by further insemination in 72-76 hours according to instructions.
For treatment of cows with postpartum endometritis and uterine subinvolution: Kloprostin shall be administered twice each 10-11 days by 2 ml with simultaneous administration of causal, pathogenetic and symptomatic therapy.
For restoration of reproductive function in breeding sows, that did not display estrus within 12 days after weaning, the drug shall be administered by 1 ml in combination with one of gonadotropic drugs (PMS (pregnant mare serum) by 10 IU per 1 kg body weight, etc.). To synchronize farrowing sows and prevention of postpartum diseases the drug shall be administered by 0.7 ml per day 113-114 of gestation. Delivery shall start in most cases after 24-35 hours.
For prevention and treatment non-disclosure of uterine cervix in pregnant sheep Kloprostin shall be administered by 2 ml 15-16 days prior to lambing. In case of vaginal prolapse 3-5 days before delivery, the drug shall be administered in the above mentioned dose with combination of 2 ml 0.1% estradiol dipropionate oil solution.
Termination of unwanted pregnancy (by prescription) is achieved by injection of Kloprostin by 2 ml.

3.3 Side effects of the drug are not observed if used in recommended doses.

3.4 Cloprostin contraindicated in pregnant animals as it causes abortion.

3.5 It is restricted to slaughtering animals for meat within 24 hours after drug administration. Meat of animals slaughtered within 24 hours after the last drug administration shall be used for fodder purposes. Milk shall be used without limitations. Slaughter of animals for meat is restricted within 48 hours after drug administration. Meat of slaughtered animals before specified deadline can be used for fodder purposes. Milk obtained from treated animals shall be used without limitations.  


4.1 A person working with this drug shall follow general personal hygiene regulations and safety precautions.  


5.1 In case of inconsistency of the drug with requirements of this Instruction, its use should be discontinued and reported to the Uzbek state scientific and veterinary drugs control laboratory at: 700178, Tashkent, No.1a, A.Yunusov Street. Tel. / Fax: 228-76-14, 229-30 - 47. E-mail: uzgnkl@rambler.ru. Simultaneously unpacked drug package should be sent to the laboratory address with the drug in quantity previously agreed with laboratory including detailed description of the nature of complications.