1.1 Klozantel-50.

1.2 The drug is a sterile clear solution with light yellow to yellow color with a weak characteristic odor. Each ml contains 50 mg closantel.

1.3 Klozantel-50 is pre-packed by 10, 20, 50, 100, 200 and 250 ml in glass or polymeric sealed vials.

1.4 The drug should be stored according to the list B in dark and dry place, out of reach of children, within the temperature range +4°C to +25°C. Shelf life of the drug is 1 year.

2.1 Mechanism of action closantel is inhibition of oxidation phosphorylation in parasites. Specific drug action is stimulation of ATF-enzyme, which leads to disruption of the phosphorylation process and electron transport changing of the parasite energy metabolism so that it leads to its death.

2.2 During parenteral administration the drug is quickly absorbed at the injection site and penetrated into organs and tissues of animals.

2.3 Maximum drug concentration in blood shall be achieved 12 hours after drug administration and retained for 24-36 hours. Therapeutic concentration of the drug in the animal body shall retain for 10-11 days.

2.4 Closantel is practically unaffected by biotransformation in the body and is eliminated mainly unchanged.


3.1 The drug is used in cattle for treatment of gastrointestinal nematodose: (haemonchosis, bunostomatosis, esophagostomiasis, strongyloidosis, trichocephalosis, cooperiosis, etc), fascioliasis, paramphistomatosis, thelaziosis, scabies and against ixodic ticks. The drug is used in goats and sheep for treatment of gastrointestinal nematodose,  ascioliasis, paramphistomatosis, dicroceliosis, scabies and oestrosis. 

3.2 The drug is administered in ruminants intramuscular and subcutaneous.

3.3 During high infestation with fasciola single dose is divided into two parts and administered by half dose for two consecutive days in animals. Dosage of the drug in animals:

Species and name of parasitic diseases
Klozantel-50 Closantel (ADB)
In Cattle:
fascioliasis, paramphistomatosis, gastrointestinal nematodose (haemonchosis, esophagostomiasis, bunostomatosis, strongyloidosis, trichocephalosis, cooperiosis, etc.), thelaziosis 0,5 ml per 10 kg animal weight  2,5 ml per kg animal weight
during attack of ixodic ticks  0,5 ml per 10 kg animal weight 2,5 мг на 1 кг веса животных
scabies: sarcoptosis, psoroptosis, chorioptosis,  (in young cattle) Twice 1 ml per 10 kg animal weight with 7 day interval 5,0 ml per kg animal weight
hypodermosis induced by larvae in 2nd and 3rd stage One time 1 ml per 10 kg animal weight 5,0 ml per kg animal weight
In ruminants:
fascioliasis, paramphistomatosis, dicroceliosis 1 ml per 10 kg animal weight 5,0 ml per kg animal weight
- gastrointestinal nematodose (haemonchosis, ostertagiosis, strongyloidosis, esophagostomiasis, chabertiosis, bunostomatosis, trichocephalosis) 1 ml per 20 kg animal weight 2,5 ml per kg animal weight
scabies (psoroptosis, chorioptosis) ml per 10 kg animal weight twice, with 7 days interval  5,0 ml per kg animal weight
oestrosis 1 ml per 20 kg animal weight 2,5 ml per kg animal weight

3.4 If total administered dose volume exceeds 10 ml, then the drug shall be administered in two different injection sites.

3.5 Side effects. In some cases there may be irritation at the injection site that disappears without medical intervention.

3.6 Contraindications. Do not use in animals with known hypersensitivity to the drug components. Do not use the drug in weakened and sick animals affected by infectious diseases. It is restricted to use the drug in milking cows and in the last trimester of pregnancy. Do not administer simultaneously with other antiparasitic drugs. Do not use simultaneously with organochlorine and chlororganic antiparasitic drugs.

3.7 Milk can be used for food purposes after 14 days, the meat - 28 days after the last drug administration in animals.


4.1 A person working with this drug shall follow general personal hygiene regulations and safety precautions.


5.1 In case of inconsistency of the drug with requirements of this Instruction, its use should be discontinued and reported to the Uzbek state scientific and veterinary drugs control laboratory at: 700178, Tashkent, No.1a, A.Yunusov Street. Tel. / Fax: 228-76-14, 229-30 - 47. E-mail: uzgnkl@rambler.ru. Simultaneously unpacked drug package should be sent to the laboratory address with the drug in quantity previously agreed with laboratory including detailed description of the nature of complications.