1.1 Levamizol-75 and Levamizol-100 is an anthelmintic drug from imidazotiazol group. Each ml of the drug contains respectively 75 mg or 100 mg levamisole.

1.2 It is clear, colorless or slightly yellow colored liquid with a faint specific odor.

1.3 The drug is available in 7.5% and 10% solution for injection, pre-packaged by 5, 10, 20, 50 or 100 ml in glass vials of relevant capacity. Packaging and labeling is made in accordance with specification requirements. Other packaging ensuring safety and quality of the drug may be agreed in the prescribed manner.

1.4 The drug should be stored in its original packaging with caution (see list ‘B’) in dark place, protected from sunlight, out of reach of children at the temperature range +5°C to +25°C. Shelf life is 2 years from date of manufacture under specified storage conditions. 


2.1 Levamisole (hydrochloride) as an active ingredient inhibits vital enzymes of nematodes (fumarate and succinate dehydrogenase). As a consequence, it is a broad-spectrum drug that causes death of adult and larval forms of parasites.

2.2 Levamisole after parenteral administration is rapidly reabsorbed from the injection site and therapeutic concentration in organs and tissues shall be achieved within 30 minutes and retained for 6-9 hours. Levamisole is eliminated mainly with urine.

2.3 Levamisole hydrochloride besides anthelmintic action has a stimulating effect on the animal’s immune system. It enhances bactericidal activity of blood serum, phagocyte activity of leukocytes, immunoglobulin level and quantity of T-lymphocytes.


3.1 The drug is administered:

- in cattle – for treatment of dictyocaulosis, haemonchosis, bunostomatosis esophagostomiasis, nematodirosis, ostertagiosis, chabertiosis, cooperiosis, strongyloidosis;       
- in ruminants – for treatment of dictyocaulosis, protostrongylidoses, haemonchosis, strongyloidosis, esophagostomiasis, cooperiosis, trichostrongylosis, nematodirosis, trichocephaliasis, chabertiosis;
- in pigs – for treatment of ascaridosis, esophagostomiasis, strongyloidiasis, trichocephaliasis, hyostrongiloses, metastrongylosis;
- in dogs – for treatment of  toxocariasis and uncinariasis.

3.2 The drug is administered one time subcutaneously or intramuscularly based on 75 mg levamisole per kg of animal weight that is equal to:

Animal species  Drug dosage Notes
Levamisole-75 Levamisole -100
Cattle (subcutaneously or intramuscularly)  1,0 ml per 10 kg 0,75 ml per 10 kg Not more than 30,0 ml in animals over 300kg 
Ruminants  (subcutaneously) 1,0 ml per 10 kg 0,75 ml per 10 kg Not more than 4,5 ml in animals over 65kg
Pigs (subcutaneously or intramuscularly) 1,0 ml per 10 kg 0,75 ml per 10 kg Not more than 20,0 ml in animals over 150kg
Dogs (subcutaneously or intramuscularly) 1,0 ml per 10 kg 0,75 ml per 10 kg

3.3 If total administered dose volume exceeds 15 ml, the drug should be administered into 2-3 different injection sites in animal.

3.4 Prior to mass deworming every batch of the drug shall be pre-tested in a small group of animals (5-10 animals). In absence of complications within 3 days you can start treatment in all livestock.

3.5 Contraindications. The drug is restricted to use in the following species:
- weak and exhausted animals affected by infectious diseases;
- animals with liver and kidney disorders;
- female animals in the last trimester of pregnancy and within 2 weeks after delivery;
- young animals, which weight does not exceed 10 kg.
In addition, the drug should not be administered within 10 days before and after use of organophosphorus agents, pyrantel, morantel, phenothiazine, levomicetine (chloramphenicol).

3.6 Side effects. The drug is well tolerated by animals in therapeutic dose. During increased individual sensitivity to the drug excitation, increased salivation, frequent urination and defecation and ataxia may be observed in some animals. These symptoms usually spontaneously disappear without application of therapeutic agents. Atropine shall be used as antidote against poisoning by levamisole in accordance with prescribed instructions.

3.7 Slaughter of animals for meat shall be allowed not earlier than 7 days after deworming. In case of compulsory slaughter of animals prior specified deadline the meat shall be used as feed for fur animals or production of meat and bone tankage. Milk obtained from milking animals treated with levamisole shall not be used for food purposes within 48 hours after deworming. It can be used for feeding animals. Drug may be administered repeatedly when required.


4.1 A person working with this drug shall follow general personal hygiene regulations and safety precautions.


5.1 In case of inconsistency of the drug with requirements of this Instruction, its use should be discontinued and reported to the Uzbek state scientific and veterinary drugs control laboratory at: 700178, Tashkent, No.1a, A.Yunusov Street. Tel. / Fax: 228-76-14, 229-30 - 47. E-mail: uzgnkl@rambler.ru. Simultaneously unpacked drug package should be sent to the laboratory address with the drug in quantity previously agreed with laboratory including detailed description of the nature of complications.