1. GENERAL INFORMATION
1.1 Makroprim concentrate.
1.2 Makroprim concentrate is a powder with white to light cream color, well soluble in water.
1.3 Each 100 g of the drug contains 5 g tylosin, 17.5g sulfamerazine, 3.5 g trimethoprim and 30 mln.ME colistin sulphate.
1.4 Makroprim concentrate is pre-packed by 50, 100, 250, 500 or 1000 g in polymer bags or by 250; 500, 1000, 2000 or 3000 g in polymer vessels
1.5 The drug should be stored according to the List B, in dry and dark place within the temperature range 0°C to +25°C.
2. PHARMACOLOGICAL PROPERTIES
2.1 Makroprim Concentrate is a combined antimicrobial drug; it has bactericidal effect against Gram-negative (E. coli, Klebsiella spp., Salmonella spp., Proteus spp., Campylobacter spp., Pseudomonasaeruginosa, Bordetella spp., Pasteurella spp., Haemophilus spp., Actinobacillus spp., Brucella spp.) and gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Listeriamonocytogenes, Erysipelothrix suis), mycoplasma, chlamydia, eimeria. Viruses and fungi are not sensitive to the drug.
2.2 Unique drug formula ensures a broad spectrum of activity against mycoplasmal, bacterial and mixed infection diseases. Tylosin combined with 50S ribosomal subunit of susceptible organisms blocks ribosome binding point with tRNA (peptidyl-tRNA) that interrupts attachment of amino acids and growth of the peptide chain. Sulfamerazine trimethoprim disrupts synthesis of purine and pyrimidine nucleotides by blocking synthesis of dihydrofolic acid. Colistin blocks phospholipid components of cytoplasmic membrane and disrupts its structure and cause bacteriolysis.
2.3 Active ingredients of the drug except for colistin sulfate are well absorbed by gastrointestinal tract and penetrate into all organs and tissues. Therapeutic concentration is retained within 12 hours. The drug is eliminated from the body with urine and faeces.
3. DRUG USAGE PROCEDURE
3.1 Makroprim Concentrate is administered for prevention and treatment of farm animals and poultry against diseases caused by microorganisms susceptible to the drug components. The drug is effective for treatment of animals with respiratory diseases, gastrointestinal and genitourinary tract affected by colibacillosis, salmonellosis, erysipelas, chlamydiosis, mycoplasmosis and other diseases, including combined diseases.
3.2 The drug is administered orally mixed with feed or water. If necessary, the drug is administered in the group form based on 1.5% premix (1.5 kg of the drug per ton of feed) and give within 5-7 days. The drug mixed with feed retains its activity for two months. Prepared drug solution should be used within 48 hours.
In large and small cattle, pigs the drug is administered based on 0.1 g per kg animal weight, twice a day with food or water for 5-7 days.
In birds the drug is administered based on 1.5 kg per 1000 kg of feed or 1 kg of the drug per 1000 liters of water for 3-5 days. During treatment birds should only receive water containing the drug.
3.3 The drug does not cause side effects if administered in recommended doses. Administration of the drug in excessive doses may cause kidney damage, agranulocytosis.
3.4 Contraindications to the drug use - increased individual sensitivity, kidney and liver diseases. Combined use with drugs containing sulfur derivatives (sodium thiosulfate, unitiol) and paraaminobenzoic acid (novocaine, anesthezine) is restricted.
3.5 In case of adverse reactions (urticaria, vomiting) the drug use shall be stopped and antihistamine drugs (diphenylhydramine, tavegil), calcium drugs and sodium carbonate shall be prescribed.
3.6 The drug is not administered in chickens, laying hens during egg-laying period and in goats.
3.7 Slaughter of animals and poultry for meat shall be allowed not earlier than eight days after the last drug administration. In case of compulsory slaughter of animal prior prescribed time, the meat shall be used to feed flesh eaters. Milk for human consumption should be used not earlier than 5 days after the last drug administration. Prior expiry of prescribed time the milk shall be used to feed animals after boiling.
4. CLAIMS PROCEDURE
4.1. In case of complications after drug administration its use should be discontinued and reported to the Uzbek State Scientific and Veterinary Drugs Control Laboratory at: (700178, Tashkent, Karakamysh 2/4, No.1a,Yunusov str.) and to the drug manufacturer. Simultaneously samples of drug’s lot should be sent to the Uzbek State Scientific and Veterinary Drugs Control Laboratory samples expelled Series drug that caused complications in animals, with detailed description of complications.