1. GENERAL INFORMATION
1.1 Metsalben 2.5% and Metsalben 10% are suspensions for oral administration.
1.2 Each ml of Metsalben 2.5% suspension contains 25 mg albendazole as an active ingredient and each ml of Metsalben 10% suspension contains 100 mg albendazole. Furthermore, in both drugs auxiliary components (gelifiers, preservatives) are included into composition.
1.3 The drug by its appearance is a homogeneous liquid with white to light gray color, flaking during storage.
1.4 The drug is prepackaged by 100, 200, 250, 500 and 1000 ml in polymeric containers.
2. PHARMACOLOGICAL PROPERTIES
2.1 Albendazole is a broad-spectrum anthelmintic, active against mature and immature nematodes, cestodes as well as against eggs and mature trematodes.
2.2 Mechanism of the albendazole action as a part of the drug is disruption of carbohydrate metabolism in helminthes, which leads to its destruction and withdrawal from the animal body. Due to its egg-killing action it reduces pasture infestation by helminthes.
2.3 Metsalben 2.5% and Metsalben 10% suspensions are moderately hazardous by degree of impact on the body. It is well tolerated by animals in recommended doses.
3. DRUG USAGE PROCEDURE
3.1 The drug is used for deworming of cattle, sheep, goats, pigs, horses in the following diseases:
- gastrointestinal nematodosis (haemonchosis, bunostomatosis, esophagostomiasis, nematodirosis, ostertagiosis, chabertiosis, cooperiosis, strongyloidosis, trichostrongylosis, giostrongilosis, parascaridosis, ascaridosis);
- pulmonary nematodosis (dictyocaulosis, protostrongylosis, mulleriosis, neostrongylosis, cystocaulosis, metastrongylosis);
- cestodiasis (monieziasis, avitellinosis, thysanieziosis);
- trematod infection (fascioliasis, dicroceliosis, paramphistomatosis).
3.2 The drug is administered orally, once, individually by dosing gun or other dosage devices in admixture with feed.
In cattle: for treatment of nematodosis and dicroceliosis Metsalben 2.5% suspension is administered in a dose 3 ml per 10 kg body weight, Metsalben 10% suspension - 3 ml per 40 kg body weight; for treatment of fascioliasis Mecalben 2.5% suspension is administered in a dose 4 ml per 10 kg animal weight, Metsalben 10% suspension - 4 ml per 40 kg animal weight.
In sheep and goats: for treatment of nematodosis, dicroceliosis, moniaziasis Metsalben 2.5% suspension is administered in a dose 2 ml per 10 kg; Metsalben 10% suspension - 2 ml per 40 kg animal weight; for treatment of fascioliasis respectively 3 ml per 10 kg and 3 ml per 40 kg animal weight.
In horses: for treatment of parascaridosis, strongylatosis, alfortiosis, delafondiosis, anoplocephalosis cyatostomosis Metsalben 10% solution is administered in a dose 7.5 ml per 100 kg body weight.
In pigs: Metsalben 2.5% Suspension is administered in a dose 2.4 ml per 10 kg; Metsalben 10% suspension - 4.2 ml per 40 kg animal weight. Suspension should be carefully stirred prior to use.
3.3 Prior to mass deworming every batch of the drug shall be pre-tested in a small group of animals (5-10 animals). In absence of complications within 3 days you can start treatment in all livestock.
3.4 No side effects have been observed by using the drug in recommended doses.
3.5 Contraindications. The drug shall not be used in acute fascioliasis, during breeding period, in sick animals with infectious diseases and emaciated animals, as well as in sheep, goats and pigs in the first half, and in cows and mares - in the first trimester of pregnancy.
3.6 Slaughter for meat of cattle, horses and pigs shall be allowed not earlier than 14 days, sheep and goats - 10 days, use of milk obtained from cows for food purposes - after 3 days and milk obtained from sheep and goats - 4 days after the last drug administration. Meat of compulsory slaughtered animals and milk obtained prior specified deadline may be used for feed purposes.
4. INDIVIDUAL PREVENTION MEASURES
4.1 All operations with the drug shall be made in protective clothing (dressing, headwear, rubber goggles). In case of accidental contact of the drug with skin or mucous membranes you must rinse with large amount of water.
4.2 Do not drink, smoke and eat during operations.
4.3 At the end of operations you should wash hands with warm water and soap; Wash and dry your gloves.
4.4 Do not use containers under the drug for other purposes.
5. CLAIMS PROCEDURE
5.1 In case of inconsistency of the drug with requirements of this Instruction, its use should be discontinued and reported to the Uzbek state scientific and veterinary drugs control laboratory at: 700178, Tashkent, No.1a, A.Yunusov Street. Tel. / Fax: 228-76-14, 229-30 - 47. E-mail: email@example.com. Simultaneously unpacked drug package should be sent to the laboratory address with the drug in quantity previously agreed with laboratory including detailed description of the nature of complications.