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METSTRAMIZOL-20%

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1. GENERAL INFORMATION
1.1 Metstramizol 20% Granulate is anthelmintic drug, containing tetramisole hydrochloride 20% as an ​​active ingredient and inactive fillers (lactose, feeding chalk, precipitated chalk or other inert ingredients).

1.2 The drug by its appearance is granulate with white or light gray color.

1.3 The drug is available in ready to use form in double plastic bags by 0.1-5.0 kg and in polymer containers by 0.5-10.0 kg.

1.4 The drug should be stored in its original packaging in dark and dry place, out of reach of the children within the temperature range +4°C to +25°C. Shelf life is 3 years from date of manufacture under specified storage conditions.

2. PHARMACOLOGICAL PROPERTIES
2.1 Tetramisole hydrochloride (DL 2,3,5,6,-tetrahydro-6-phenyl-imidazo-(2,1-b) thiazole hydrochloride) as an active ingredient of the drug inhibits activity of fumarate and succinate dehydrogenase in nematodes and causes death of mature and larval forms of parasites.

2.2 Tetramisole hydrochloride belongs to low-toxic compounds and is well absorbed through digestive tract of animals, it does not have embryo toxic, sensitizing, teratogenic and cumulative effects, it does not irritate the skin and mucous membranes.

 

3. DRUG USAGE PROCEDURE      
3.1 Metstramizol20% granulate is administered in cattle, sheep and goats, pigs, horses, dogs and fur animals for treatment of gastro-intestinal and pulmonary nematodes (gastrointestinal strongyloidiasis, ascaridosis, trichocephaliasis, esophagostomiasis, strongyloidosis oxyuriasis, parascaridosis, toxascaridosis, uncinariasis, etc.).

3.2 The drug is administered with food by group method twice (once a day for two consecutive days) in the following doses (mg per 1 kg animal weight)

Animal species and names of helminthoses Frequency of administration
Dosage 
Metstramizol 20% Granulate
Tetramisole Hydrochloride (ADB)
In cattle:
- strongylatosis of gastrointestinal tract, strongyloidosis
Twice
50
10
In ruminants:
- strongylatosis of gastrointestinal tract, strongyloidosis (dictyocaulosis, haemonchosis, bunostomosis, ostertagiosis, chabertiosis, cooperiosis, strongyloidosis,)
Twice
37,5
7,5
In pigs:
- ascaridosis, trichocephaliasis esophagostomiasis
Twice
75
15
In horses:
- parascaridosis;
-oxyuriasis, strongylatosis of gastrointestinal tract, strongyloidosis
Twice
Twice
50
75
10
15
In dogs: 
- toxascaridosis, toxocariasis, uncinariosis
Twice
100
20
Fur-bearing animals:
- toxascaridosis, toxocariasis, uncinariosis
Once
100
20

3.3 The drug does not have side effects in the recommended doses.

3.4 Slaughter of animals for meat shall be allowed not earlier than 7 days and use of milk for food purposes shall be allowed 2 days after the last drug administration. Meat of compulsory slaughtered animals and milk obtained prior expiry of specified period can be used to feed animals.

 

4. INDIVIDUAL PREVENTION MEASURES
4.1 A person working with this drug shall follow general personal hygiene regulations and safety precautions, envisaged for operations with veterinary drugs.

4.2 At the end of operations you should wash your hands with warm water and soap.

 

5. CLAIMS PROCEDURE
5.1 In case of inconsistency of the drug with requirements of this Instruction, its use should be discontinued and reported to the Uzbek state scientific and veterinary drugs control laboratory at: 700178, Tashkent, No.1a, A.Yunusov Street. Tel. / Fax: 228-76-14, 229-30 - 47. E-mail: uzgnkl@rambler.ru. Simultaneously unpacked drug package should be sent to the laboratory address with the drug in quantity previously agreed with laboratory including detailed description of the nature of complications.