1.1.    Sulfaprim is an antibacterial drug where sulfamerazine and trimethoprim are active ingredients.

1.2 Sulfaprim is produced in the form of powder, granules and tablets. The drug by its appearance is a water-soluble uniform crystalline powder white to cream color or granules of various shapes white to cream color or tablets of round shape white or white with yellow shading.Each tablet contains 0.48 g active substance (0.4 g sulfamerazine and 0.08 trimethoprim).

1.3 The drug is pre-packaged:  in opaque polymer pots by 50, 100, 250, 500, 1,000 tablets or in blisters from composite materials by 10-50 pcs.
1.4 The drug should be stored with caution (see List B ) in a dry, dark place within the temperature range from 0ºC to +25ºC Shelf life is 2 years under specified storage conditions.


2.1 Components included in the drug have a synergistic effect and determine its high antimicrobial activity. The drug suppresses development of many Gram-positive and Gram-negative microorganisms, including Salmonella, Pasteurella, Escherichia, but it is not active against fungi and viruses.

Drug affects folic acid biosynthesis in microorganisms.

2.2 After oral administration the drug is quickly absorbed by gastrointestinal tract and is penetrated through organs and tissues and it has bactericidal effect. Maximum concentration in blood is reached 2-4 hours after drug administration. Therapeutic concentration in blood retains for 12 hours. The drug is eliminated mainly with urine.

3.1 Sulfaprim is used in young animals against pneumonia, catarrhal pneumonia, bronchitis, laryngitis, tonsillitis, sepsis, necrobacillosis in sheep and reindeers, dyspepsia, gastroenteritis, urinary tract infections, salmonellosis, pasteurellosis, respiratory mycoplasmosis, eimeriosis in poultry and other diseases, which pathogens are sensitive to the drug components.

3.2 1 tablet per 15 kg of animal weight or 30 mg active substance per 1 kg. Tablets are administered with food, drinking water or directly to animal’s tongue root. During treatment animals shall be provided with free access to water. Birds are prescribed 1.0 g per 5 kg feed 2 times a day with 12 hours interval within 3-5 days. Sulfaprim may be used in combination with antibiotics. In such cases antimicrobial spectrum and therapeutic properties shall be substantially increased.

3.3 Side effects at recommended dosages as a rule are not observed. Loss of appetite, diarrhea and vomiting may be observed if animals have individual hypersensitivity to sulfonamides. In such cases use of drug should be discontinued.

3.4 Application of sulfaprim shall be contraindicated at blood diseases, acute hepatitis, nephritis and hypersensitivity to the drug components. It is forbidden to use this drug in milking animals.

3.5 Slaughtering of animals for meat shall be allowed 7 days, and poultry 12 days after the last drug administration. Meat of animals during urgent slaughter before expiry of specified period shall be used to feed flesh eaters or for production of meat and bone meal tankage. Milk shall be allowed for consumption to humans not earlier than four days after the last drug administration. Before expiry of specified period such milk can be used for feeding animals after boiling.      

4.1 In case of inconsistency of the drug with requirements of this Instruction, its use should be discontinued and reported to the Uzbek State Scientific and Veterinary Drugs Control Laboratory at: 700178, Tashkent, No.1a, A.Yunusov Street. Tel. / Fax: 228-76-14, 229-30 - 47. E-mail: uzgnkl@rambler.ru. Simultaneously unpacked drug package should be sent to the laboratory address with the drug in quantity previously agreed with laboratory including detailed description of the nature of complaints regarding its inconsistency with this Instruction.