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VETILOZIN - 50; 200

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1. GENERAL INFORMATION
1.1 Vetilozin-50 and Vetilozin-200 is a drug containing 50 mg and 200 mg of tylosin respectively in 1 ml as well as ancillary components.

1.2 The product is a clear sterile solution without visible mechanical impurities from light yellow to yellow color.

1.3 Vetilozin-50 and Vetilozin-200 is prepackaged in glass or polymer vials by 10, 20, 50, 100, 200 and 250 ml.

1.4 The drug should be stored with caution (see List B) in a dry, dark place and kept out of the reach of children within the temperature range from +5ºC to +20ºC. Shelf life is 2 years under specified storage conditions.

2. PHARMACOLOGICAL PROPERTIES
2.1 Tylosin affects most Gram-positive and some gram-negative bacteria including Streptococcus, Leptospira, Corynebacterium, Clostridium, erysipelothrix, Pasteurella, chlamydia, treponema hyodisenteriae, spirochetes and mycoplasma.

2.2 During intramuscular injection antibiotic is quickly distributed throughout the body and reaches maximum concentration in tissue approximately 1 hour after the drug administration. Therapeutic effect of this antibiotic in tissues retains for at least 20 hours. It is eliminated primarily with urine and with milk in lactating animals.  

 

3. DRUG USAGE PROCEDURE
3.1. Drugs are used as a remedy for respiratory diseases (rhinitis , tonsillitis, laryngitis, bronchitis, pneumonia, etc.) in cattle and small ruminants, pigs, dogs and  cats; during mastitis in cattle; enzootic pneumonia, arthritis, dysentery, atrophic rhinitis and swine erysipelas; infectious agalactia in sheep and goats, campylobacteriosis (vibriosis) in cattle and small ruminants; felon, otitis with bacterial etiology and infected wounds; infectious conjunctivitis in calves and cows as well as during secondary bacterial infections at viral diseases.

3.2. Drugs shall be applied in animals intramuscularly once a day within 3 days with the following dosage (based on 1 kg of animal weight):

 

Animal type Active substance dose – Tylosin (mg/kg) Drugs dosage
Vetilozin -50 (ml/kg) Vetilozin-200 (ml/kg)
Cattle 4-10 0,8-2,0 0,2-0,5
Sheep and goats  5-10 1,0-2,0 0,25-0,5
Pigs 2-10 0,4-2,0 0,1-0,5
Dogs and cats 2-10 0,4-2,0 0,1-0,5

3.3 Specific directions. It is not recommended to inject more than 5 ml of the drug into one spot in sheep, goats and pigs and more than 10 ml into cattle as well as mix with other drugs in the same syringe. It is inappropriate to use Vetilozin-50 for treatment of cattle weighing more than 80 kg and other animals with a weight more than 10 kg.

3.4 Adverse effects. Very rare there may be allergic reactions in pigs in the form of erythema, itching, respiratory effects, light edema with a slight protrusion of rectum which quickly disappear after discontinue of the drug use. Respiration and pulse can be increased in cattle.

3.5 Contra indications. Do not use the drug in conjunction with penicillin (especially with ampicillin and oxacillin), cephalosporin and lincomycin due to significant reduction of tylozin antibacterial effect as well as due to increased sensitivity to drug components. This drug is not recommended to use in horses.

3.6 Slaughtering of animals for meat shall be allowed 8 days after cessation of the drug administration. Meat of animals slaughtered before expiry of specified period shall be used to feed flesh eaters or for production of meat and bone meal tankage. Milk obtained from animals during treatment and until expiry of four days after the last drug administration shall not be used for food purposes. Such milk may be used for feeding animals.    

 

4. INDIVIDUAL PREVENTION MEASURES
4.1 A person working with this drug shall follow general personal hygiene regulations and safety precautions.

4.2 After handling the product you should carefully wash hands and face with warm water.

 

5. CLAIMS PROCEDURE
5.1 In case of inconsistency of the drug with requirements of this Instruction, its use should be discontinued and reported to the Uzbek State Scientific and Veterinary Drugs Control Laboratory at: 700178, Tashkent, No.1a, A.Yunusov Street. Tel. / Fax: 228-76-14, 229-30 - 47. E-mail: uzgnkl@rambler.ru. Simultaneously unpacked drug package should be sent to the laboratory address with the drug in quantity previously agreed with laboratory including detailed description of the nature of complaints regarding its inconsistency with these Instructions.