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SELEN+VITAMIN E

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1. GENERAL INFORMATION
1.1. Selenium+Vitamin ‘E’ (Selenium+Vitaminum E) is a solution for injection.

1.2 The drug contains vitamin E (α-tocopherol acetate) and selenium in the form of sodium selenite. Each ml of the drug contains 50 mg of vitamin E and 1 mg of selenium.

1.3. Selene + Vitamin E is a clear, colorless or slightly yellowish liquid (opalescence is permissible) with weak specific smell.

1.4. The drug is available in glass vials by 10, 20, 50, 100, 200 and 250 ml. the drug should be stored according to the List B in dry place, protected from direct sunlight, within the temperatures range +5°C to +25°C. Shelf-life of the drug is 2 years if stored in specified storage conditions.

2. PHARMACOLOGICAL PROPERTIES
2.1 Selenium + Vitamin E compensate deficiency of vitamin ‘E’ and selenium in animal organism.
Vitamin ‘E’ regulates redox processes and influences carbohydrate and fat metabolism, enhances action of vitamins A and D3. It also affects the immune status, overall resistance and reproductive function.
Selenium contributes significantly to the effectiveness of vitamin E and takes part in the redox processes as well.

2.2 Injection of the drug in body leads to rapid increase of Vitamin E and selenium level in blood and other tissues.

 

3. DRUG USAGE PROCEDURE
3.1 The drug is used to prevent diseases caused by deficiency of selenium and vitamin E, for treatment of animals sick with white muscle disease as well as a drug for pathogenetic therapy, improvement of metabolism, improvement of reproductive capacity in females, natural resistance in young animals and its resistance to adverse environmental factors, for treatment of toxic liver disease in animals as well as at stunted growth and inadequate weight gain, against encephalomalacia and exudative diathesis in birds.

3.2 The drug is administered in all kinds of animals intramuscularly or subcutaneously (only horses intramuscularly) for preventive treatment once every 2-4 months in the dose:


- in adult animals (cattle, sheep, goats, pigs and horses): 1 ml per 50 kg of animal weight;
- in young farm animals: 0.2 ml per 10 kg of animal weight;
- in dogs, cats and fur-bearing animals: 0.04 ml per 1 kg of animal weight.


In poultry the drug is administered based on 130 ml per 1000-2000 liters of water. As prevention treatment the drug is administered in chickens starting one day old once every 2-3 weeks, in adult birds - once per month; with treatment purpose - 2-3 times with intervals 1-2 weeks.
With treatment purpose the dose can be increased by not more than 1.5 times. If necessary, the drug is administered again after 7-10 days.

3.3 Specific guidance. During drug overdose toxic effects may be occurred that’s why a dose for one animal should not exceed: 20 ml in horses, 15 ml in cows and 5 ml in sheep, goats and pigs. In young pigs the drug is used not earlier 8 days old. It is necessary to make a tolerance test in 3-4 animals before mass treatment. Observation time is 1 day.

3.4 Contraindications. Drug administration is restricted in animals with individual hypersensitivity to selenium or after treatment of animals during the past 10 days with other drugs containing selenium.

3.5 The drug does not cause side effects and complications in animals if administered in recommended doses. In case of anaphylactic reaction adrenaline should be injected immediately. During poisoning due to overdose in animals arsanilic acid or sodium arsanilic acid (atoxyl) should be used for treatment based on 1.5-2 mg per kg of animal weight. Unitiol, sodium thiosulfate and methionine are used as well.

3.6 Meat, milk and eggs obtained from animals and birds that underwent drug treatment can be used for food purposes without restrictions.

 

4. CLAIMS PROCEDURE
4.1 In case of complications after drug administration its use should be discontinued and reported to the Uzbek State Scientific and Veterinary Drugs Control Laboratory at: 700178, Tashkent, No.1a, A.Yunusov str.,Tel/Fax: 228-76-14, 229-30-47. E-mal: uzgnkl@rambler.ru. Simultaneously unpacked drug package should be sent to the laboratory address with the drug in quantity previously agreed with laboratory including detailed description of the nature of complaints regarding its inconsistency with these Instructions.